TY  - GEN
AU  - Alvarez,Sergio E
AU  - Harikumar,Kuzhuvelil B
AU  - Hait,Nitai C
AU  - Allegood,Jeremy
AU  - Strub,Graham M
AU  - Kim,Eugene Y
AU  - Maceyka,Michael
AU  - Jiang,Hualiang
AU  - Luo,Cheng
AU  - Kordula,Tomasz
AU  - Milstien,Sheldon
AU  - Spiegel,Sarah
TI  - Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2
SN  - 1476-4687
PY  - 2010///0721
KW  - Animals
KW  - Biocatalysis
KW  - Cell Line
KW  - Enzyme Activation
KW  - Humans
KW  - I-kappa B Kinase
KW  - metabolism
KW  - I-kappa B Proteins
KW  - Lysine
KW  - Lysophospholipids
KW  - biosynthesis
KW  - Mice
KW  - Models, Molecular
KW  - NF-KappaB Inhibitor alpha
KW  - NF-kappa B
KW  - Phosphorylation
KW  - Phosphotransferases (Alcohol Group Acceptor)
KW  - genetics
KW  - Protein Binding
KW  - Protein Structure, Tertiary
KW  - Receptor-Interacting Protein Serine-Threonine Kinases
KW  - Sphingosine
KW  - analogs & derivatives
KW  - Substrate Specificity
KW  - TNF Receptor-Associated Factor 2
KW  - chemistry
KW  - Tumor Necrosis Factor-alpha
KW  - pharmacology
KW  - Ubiquitin-Conjugating Enzymes
KW  - Ubiquitin-Protein Ligases
KW  - Ubiquitination
KW  - drug effects
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nature09128
ER  -