TY - GEN AU - Soares,Holly D TI - The use of mechanistic biomarkers for evaluating investigational CNS compounds in early drug development SN - 2040-3429 PY - 2010///1005 KW - Animals KW - Biomarkers, Pharmacological KW - metabolism KW - Central Nervous System Agents KW - pharmacology KW - Clinical Trials, Phase I as Topic KW - methods KW - Clinical Trials, Phase II as Topic KW - Drug Discovery KW - Humans KW - Positron-Emission Tomography KW - Translational Research, Biomedical N1 - Publication Type: Journal Article; Review ER -