Zhang, Xu-Feng
A-887826 is a structurally novel, potent and voltage-dependent Na(v)1.8 sodium channel blocker that attenuates neuropathic tactile allodynia in rats. [electronic resource]
- Neuropharmacology Sep 2010
- 201-7 p. digital
Publication Type: Journal Article
ISSN: 1873-7064
Standard No.: 10.1016/j.neuropharm.2010.05.009 doi
Subjects--Topical Terms: Animals Biophysics Cells, Cultured Disease Models, Animal Dose-Response Relationship, Drug Electric Stimulation--methods Ganglia, Spinal--cytology Humans Hyperalgesia--drug therapy Male Membrane Potentials--drug effects Morpholines--chemistry NAV1.8 Voltage-Gated Sodium Channel Neuralgia--complications Niacinamide--analogs & derivatives Pain Threshold--drug effects Patch-Clamp Techniques--methods Rats Rats, Sprague-Dawley Sensory Receptor Cells--drug effects Sodium Channel Blockers--chemistry Sodium Channels--drug effects Spinal Cord Injuries--complications Tetrodotoxin--pharmacology Transfection--methods