TY - GEN AU - Carretero,Julian AU - Shimamura,Takeshi AU - Rikova,Klarisa AU - Jackson,Autumn L AU - Wilkerson,Matthew D AU - Borgman,Christa L AU - Buttarazzi,Matthew S AU - Sanofsky,Benjamin A AU - McNamara,Kate L AU - Brandstetter,Kathleyn A AU - Walton,Zandra E AU - Gu,Ting-Lei AU - Silva,Jeffrey C AU - Crosby,Katherine AU - Shapiro,Geoffrey I AU - Maira,Sauveur-Michel AU - Ji,Hongbin AU - Castrillon,Diego H AU - Kim,Carla F AU - García-Echeverría,Carlos AU - Bardeesy,Nabeel AU - Sharpless,Norman E AU - Hayes,Neil D AU - Kim,William Y AU - Engelman,Jeffrey A AU - Wong,Kwok-Kin TI - Integrative genomic and proteomic analyses identify targets for Lkb1-deficient metastatic lung tumors SN - 1878-3686 PY - 2010///0817 KW - AMP-Activated Protein Kinase Kinases KW - AMP-Activated Protein Kinases KW - Animals KW - Carcinoma, Non-Small-Cell Lung KW - genetics KW - Cell Adhesion KW - Cell Line, Tumor KW - Cell Movement KW - Cell Transdifferentiation KW - Drug Therapy, Combination KW - Enzyme Inhibitors KW - therapeutic use KW - Female KW - Focal Adhesion Protein-Tyrosine Kinases KW - antagonists & inhibitors KW - Focal Adhesions KW - Gene Expression Profiling KW - Gene Expression Regulation, Neoplastic KW - Genomics KW - Humans KW - Intracellular Signaling Peptides and Proteins KW - Lung Neoplasms KW - drug therapy KW - MAP Kinase Kinase 1 KW - MAP Kinase Kinase 2 KW - Mice KW - Mice, Mutant Strains KW - Mice, Nude KW - Neoplasm Metastasis KW - Phosphoinositide-3 Kinase Inhibitors KW - Phosphorylation KW - Protein Kinase Inhibitors KW - pharmacology KW - Protein Serine-Threonine Kinases KW - Protein-Tyrosine Kinases KW - Proteomics KW - Proto-Oncogene Proteins KW - Proto-Oncogene Proteins p21(ras) KW - RNA Interference KW - Signal Transduction KW - drug effects KW - TOR Serine-Threonine Kinases KW - Up-Regulation KW - Xenograft Model Antitumor Assays KW - ras Proteins KW - src-Family Kinases N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.ccr.2010.04.026 ER -