TY - GEN AU - Quesada-Soriano,Indalecio AU - Parker,Lorien J AU - Primavera,Alessandra AU - Wielens,Jerome AU - Holien,Jessica K AU - Casas-Solvas,Juan M AU - Vargas-Berenguel,Antonio AU - Aguilera,Ana M AU - Nuccetelli,Marzia AU - Mazzetti,Anna P AU - Lo Bello,Mario AU - Parker,Michael W AU - GarcĂ­a-Fuentes,Luis TI - Diuretic drug binding to human glutathione transferase P1-1: potential role of Cys-101 revealed in the double mutant C47S/Y108V SN - 1099-1352 PY - 2011///0616 KW - Amino Acid Substitution KW - Calorimetry KW - Crystallography, X-Ray KW - Cysteine KW - genetics KW - Diuretics KW - metabolism KW - Enzyme Activation KW - Ethacrynic Acid KW - Glutathione KW - Glutathione S-Transferase pi KW - chemistry KW - Humans KW - Hydrogen-Ion Concentration KW - Kinetics KW - Models, Molecular KW - Mutant Proteins KW - Mutation KW - Protein Multimerization KW - Structure-Activity Relationship KW - Substrate Specificity KW - Thermodynamics N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1002/jmr.1040 ER -