Pharmacokinetic-pharmacodynamic modeling of tumor growth inhibition and biomarker modulation by the novel phosphatidylinositol 3-kinase inhibitor GDC-0941. [electronic resource]
- Drug metabolism and disposition: the biological fate of chemicals Sep 2010
- 1436-42 p. digital
Publication Type: Journal Article
1521-009X
10.1124/dmd.110.032912 doi
Animals Biomarkers--metabolism Breast Neoplasms--pathology Cell Division--drug effects Dose-Response Relationship, Drug Female Humans Indazoles--pharmacokinetics Mice Mice, Nude Phosphoinositide-3 Kinase Inhibitors Phosphorylation Protein Kinase Inhibitors--pharmacokinetics Sulfonamides--pharmacokinetics