The chemopreventive retinoid 4HPR impairs prostate cancer cell migration and invasion by interfering with FAK/AKT/GSK3beta pathway and beta-catenin stability. [electronic resource]
- Molecular cancer Jun 2010
- 142 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1476-4598
10.1186/1476-4598-9-142 doi
Anticarcinogenic Agents--pharmacology Blotting, Western Bone Morphogenetic Protein 2--biosynthesis Cell Line, Tumor Fenretinide--pharmacology Focal Adhesion Protein-Tyrosine Kinases--metabolism Gene Silencing Glycogen Synthase Kinase 3--metabolism Glycogen Synthase Kinase 3 beta Humans Male Neoplasm Invasiveness Neoplasm Metastasis Prostatic Neoplasms--enzymology Proto-Oncogene Proteins c-akt--metabolism beta Catenin--genetics