Redondo-Muņoz, Javier <br/><br/>
Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation.  [electronic resource] 

 -  Clinical cancer research : an official journal of the American Association for Cancer Research  Sep 2010 
 - 4382-91 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1557-3265 
<br/><br/><label>Standard No.: </label>10.1158/1078-0432.CCR-10-0072  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adult<br/>Aged<br/>Aged, 80 and over<br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Arsenic Trioxide<br/>Arsenicals--pharmacology<br/>Blotting, Western<br/>Cell Survival--drug effects<br/>Dose-Response Relationship, Drug<br/>Enzyme Activation--drug effects<br/>Female<br/>Humans<br/>JNK Mitogen-Activated Protein Kinases--genetics<br/>Leukemia, Lymphocytic, Chronic, B-Cell--metabolism<br/>Male<br/>Membrane Potential, Mitochondrial--drug effects<br/>Microscopy, Confocal<br/>Middle Aged<br/>Oxides--pharmacology<br/>PTEN Phosphohydrolase--metabolism<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>RNA Interference<br/>Signal Transduction--drug effects<br/>Tumor Cells, Cultured<br/>Up-Regulation--drug effects