Wilson, C H <br/><br/>
The activating mutation R201C in GNAS promotes intestinal tumourigenesis in Apc(Min/+) mice through activation of Wnt and ERK1/2 MAPK pathways.  [electronic resource] 

 -  Oncogene  Aug 2010 
 - 4567-75 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1476-5594 
<br/><br/><label>Standard No.: </label>10.1038/onc.2010.202  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adenoma--enzymology<br/>Adenomatous Polyposis Coli Protein--metabolism<br/>Alleles<br/>Animals<br/>Cell Differentiation--genetics<br/>Cell Proliferation<br/>Chromogranins<br/>Colorectal Neoplasms--enzymology<br/>Cyclic AMP--metabolism<br/>Disease Progression<br/>Epithelial Cells--metabolism<br/>Female<br/>GTP-Binding Protein alpha Subunits, Gs--genetics<br/>Gene Expression Regulation, Neoplastic<br/>Genetic Loci--genetics<br/>Humans<br/>Intestinal Mucosa--metabolism<br/>MAP Kinase Signaling System<br/>Male<br/>Membrane Glycoproteins--genetics<br/>Mice<br/>Mitogen-Activated Protein Kinase 1--metabolism<br/>Mitogen-Activated Protein Kinase 3--metabolism<br/>Mutant Proteins--genetics<br/>Mutation<br/>Organ Specificity<br/>Phosphoric Diester Hydrolases--metabolism<br/>Promoter Regions, Genetic--genetics<br/>Stem Cells--metabolism<br/>Substrate Specificity<br/>Up-Regulation<br/>Wnt Proteins--metabolism