Chiou, Shiun-Kwei

Suppression of growth arrest and DNA damage-inducible 45alpha expression confers resistance to sulindac and indomethacin-induced gastric mucosal injury. [electronic resource] - The Journal of pharmacology and experimental therapeutics Sep 2010 - 693-702 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

1521-0103

10.1124/jpet.110.168153 doi


Animals
Anti-Inflammatory Agents, Non-Steroidal--toxicity
Antisense Elements (Genetics)--pharmacology
Apoptosis--drug effects
Caspase 9--metabolism
Caspase Inhibitors
Cell Cycle Proteins--antagonists & inhibitors
Cell Proliferation--drug effects
Cyclooxygenase 1--metabolism
Cyclooxygenase 2 Inhibitors--pharmacology
Cyclooxygenase Inhibitors--pharmacology
DNA Damage
Dinoprostone--pharmacology
Endothelial Cells--drug effects
Enzyme Activation--drug effects
Gastric Mucosa--pathology
Humans
Indomethacin--toxicity
Mice
Mice, Inbred C57BL
Mice, Knockout
Nuclear Proteins--antagonists & inhibitors
RNA, Small Interfering--pharmacology
Rats
Reverse Transcriptase Polymerase Chain Reaction
Stomach Ulcer--chemically induced
Sulindac--toxicity
Up-Regulation