TY - GEN AU - Berndt,N AU - Yang,H AU - Trinczek,B AU - Betzi,S AU - Zhang,Z AU - Wu,B AU - Lawrence,N J AU - Pellecchia,M AU - Schönbrunn,E AU - Cheng,J Q AU - Sebti,S M TI - The Akt activation inhibitor TCN-P inhibits Akt phosphorylation by binding to the PH domain of Akt and blocking its recruitment to the plasma membrane SN - 1476-5403 PY - 2011///0321 KW - 3-Phosphoinositide-Dependent Protein Kinases KW - Acenaphthenes KW - metabolism KW - Animals KW - Apoptosis KW - Cell Line, Tumor KW - Cell Membrane KW - Epidermal Growth Factor KW - Fluorescent Antibody Technique KW - Gene Amplification KW - Humans KW - Intracellular Signaling Peptides and Proteins KW - Magnetic Resonance Spectroscopy KW - Membrane Proteins KW - Phosphoproteins KW - chemistry KW - Phosphorylation KW - drug effects KW - Polymerase Chain Reaction KW - Protein Serine-Threonine Kinases KW - Protein Structure, Tertiary KW - Proto-Oncogene Proteins c-akt KW - Ribonucleotides KW - Signal Transduction KW - Surface Plasmon Resonance KW - TOR Serine-Threonine Kinases N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural UR - https://doi.org/10.1038/cdd.2010.63 ER -