Feldmann, Georg <br/><br/>
Inhibiting the cyclin-dependent kinase CDK5 blocks pancreatic cancer formation and progression through the suppression of Ras-Ral signaling.  [electronic resource] 

 -  Cancer research  Jun 2010 
 - 4460-9 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1538-7445 
<br/><br/><label>Standard No.: </label>10.1158/0008-5472.CAN-09-1107  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adaptor Proteins, Signal Transducing--biosynthesis<br/>Animals<br/>Cell Cycle Proteins--biosynthesis<br/>Cell Growth Processes--drug effects<br/>Cell Line, Tumor<br/>Cell Movement--drug effects<br/>Cyclin-Dependent Kinase 5--antagonists & inhibitors<br/>Down-Regulation<br/>Gene Knockdown Techniques<br/>Humans<br/>MAP Kinase Signaling System--drug effects<br/>Mice<br/>Pancreatic Neoplasms--enzymology<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>Signal Transduction<br/>Xenograft Model Antitumor Assays<br/>ral GTP-Binding Proteins--antagonists & inhibitors<br/>ras Proteins--antagonists & inhibitors