TY - GEN AU - Zwelling,L A AU - Slovak,M L AU - Doroshow,J H AU - Hinds,M AU - Chan,D AU - Parker,E AU - Mayes,J AU - Sie,K L AU - Meltzer,P S AU - Trent,J M TI - HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II SN - 0027-8874 PY - 1990///1023 KW - ATP Binding Cassette Transporter, Subfamily B, Member 1 KW - Amsacrine KW - pharmacology KW - Catalase KW - metabolism KW - Cell Line KW - Cell Nucleus KW - DNA Probes KW - DNA Topoisomerases, Type II KW - isolation & purification KW - Doxorubicin KW - Drug Resistance KW - genetics KW - Etoposide KW - Fibrosarcoma KW - Glucosephosphate Dehydrogenase KW - Glutathione Peroxidase KW - Glutathione Reductase KW - Glutathione Transferase KW - Humans KW - Kinetics KW - Membrane Glycoproteins KW - analysis KW - Neoplasm Proteins KW - Superoxide Dismutase KW - Topoisomerase II Inhibitors N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S UR - https://doi.org/10.1093/jnci/82.19.1553 ER -