TY  - GEN
AU  - Tong,Youren
AU  - Yamaguchi,Hiroo
AU  - Giaime,Emilie
AU  - Boyle,Scott
AU  - Kopan,Raphael
AU  - Kelleher,Raymond J
AU  - Shen,Jie
TI  - Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
SN  - 1091-6490
PY  - 2010///0629
KW  - Aging
KW  - Animals
KW  - Apoptosis
KW  - Autophagy
KW  - Dopamine
KW  - metabolism
KW  - Homeostasis
KW  - Kidney Diseases
KW  - genetics
KW  - Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
KW  - Lysosomes
KW  - Mice
KW  - Mice, Knockout
KW  - Oxidation-Reduction
KW  - Protein Serine-Threonine Kinases
KW  - deficiency
KW  - Ubiquitination
KW  - alpha-Synuclein
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1073/pnas.1004676107
ER  -