Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit. [electronic resource]
- Journal of pharmacological and toxicological methods
- 40-6 p. digital
Publication Type: Journal Article
1873-488X
10.1016/j.vascn.2010.04.010 doi
Animals Anti-Arrhythmia Agents--pharmacology Arrhythmias, Cardiac--chemically induced Cell Line ERG1 Potassium Channel Electrocardiography Embryo, Mammalian Ether-A-Go-Go Potassium Channels--metabolism Heart--drug effects Humans Ion Channels--antagonists & inhibitors Kidney Long QT Syndrome--chemically induced Male Methoxamine--pharmacology Models, Statistical Phenethylamines--pharmacology Rabbits Rats Sulfonamides--pharmacology Torsades de Pointes--chemically induced