TY - GEN AU - Kalender,Adem AU - Selvaraj,Anand AU - Kim,So Young AU - Gulati,Pawan AU - Brûlé,Sophie AU - Viollet,Benoit AU - Kemp,Bruce E AU - Bardeesy,Nabeel AU - Dennis,Patrick AU - Schlager,John J AU - Marette,André AU - Kozma,Sara C AU - Thomas,George TI - Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner SN - 1932-7420 PY - 2010///0806 KW - AMP-Activated Protein Kinases KW - metabolism KW - Amino Acid Sequence KW - Animals KW - Cell Line KW - Drosophila KW - Glucose KW - Hypoglycemic Agents KW - pharmacology KW - Mechanistic Target of Rapamycin Complex 1 KW - Metformin KW - Mice KW - Molecular Sequence Data KW - Monomeric GTP-Binding Proteins KW - Multiprotein Complexes KW - Phenformin KW - Proteins KW - Sequence Alignment KW - Signal Transduction KW - TOR Serine-Threonine Kinases KW - Transcription Factors KW - antagonists & inhibitors KW - Tuberous Sclerosis Complex 1 Protein KW - Tuberous Sclerosis Complex 2 Protein KW - Tumor Suppressor Proteins N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1016/j.cmet.2010.03.014 ER -