TY  - GEN
AU  - Grimshaw,Kyla M
AU  - Hunter,Lisa-Jane K
AU  - Yap,Timothy A
AU  - Heaton,Simon P
AU  - Walton,Mike I
AU  - Woodhead,Steven J
AU  - Fazal,Lynsey
AU  - Reule,Matthias
AU  - Davies,Thomas G
AU  - Seavers,Lisa C
AU  - Lock,Victoria
AU  - Lyons,John F
AU  - Thompson,Neil T
AU  - Workman,Paul
AU  - Garrett,Michelle D
TI  - AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth
SN  - 1538-8514
PY  - 2010///0820
KW  - Administration, Oral
KW  - Animals
KW  - Antineoplastic Agents
KW  - administration & dosage
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Dose-Response Relationship, Drug
KW  - Down-Regulation
KW  - HCT116 Cells
KW  - HT29 Cells
KW  - Humans
KW  - Male
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mice, Nude
KW  - Models, Biological
KW  - Models, Molecular
KW  - Neoplasms
KW  - drug therapy
KW  - Oncogene Protein v-akt
KW  - antagonists & inhibitors
KW  - Piperidines
KW  - Protein Kinase Inhibitors
KW  - Pyrazoles
KW  - Ribosomal Protein S6 Kinases, 70-kDa
KW  - Treatment Outcome
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1158/1535-7163.MCT-09-0986
ER  -