Grimshaw, Kyla M <br/><br/>
AT7867 is a potent and oral inhibitor of AKT and p70 S6 kinase that induces pharmacodynamic changes and inhibits human tumor xenograft growth.  [electronic resource] 

 -  Molecular cancer therapeutics  May 2010 
 - 1100-10 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1538-8514 
<br/><br/><label>Standard No.: </label>10.1158/1535-7163.MCT-09-0986  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Administration, Oral<br/>Animals<br/>Antineoplastic Agents--administration & dosage<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Dose-Response Relationship, Drug<br/>Down-Regulation--drug effects<br/>HCT116 Cells<br/>HT29 Cells<br/>Humans<br/>Male<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Nude<br/>Models, Biological<br/>Models, Molecular<br/>Neoplasms--drug therapy<br/>Oncogene Protein v-akt--antagonists & inhibitors<br/>Piperidines--administration & dosage<br/>Protein Kinase Inhibitors--administration & dosage<br/>Pyrazoles--administration & dosage<br/>Ribosomal Protein S6 Kinases, 70-kDa--antagonists & inhibitors<br/>Treatment Outcome<br/>Xenograft Model Antitumor Assays