Bright, S A

Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo. [electronic resource] - British journal of cancer May 2010 - 1474-82 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1532-1827

10.1038/sj.bjc.6605670 doi


Adult
Aged
Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Blotting, Western
Cell Line, Tumor
Cell Separation
Cell Survival--drug effects
Drug Resistance, Neoplasm--drug effects
Female
Flow Cytometry
Genes, abl--genetics
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--drug therapy
Male
Mice
Mice, Inbred BALB C
Middle Aged
Mutation
Oxazepines--pharmacology
Pyrroles--pharmacology