Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism. [electronic resource]
- British journal of cancer Apr 2010
- 1371-7 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1532-1827
10.1038/sj.bjc.6605653 doi
Aged Alanine Transaminase--metabolism Antineoplastic Agents--adverse effects Bilirubin--metabolism Carcinoma, Renal Cell--drug therapy Clinical Trials, Phase II as Topic Clinical Trials, Phase III as Topic Female Genotype Gilbert Disease--genetics Glucuronosyltransferase--antagonists & inhibitors Humans Hyperbilirubinemia--chemically induced Indazoles Kidney Neoplasms--drug therapy Liver--enzymology Male Middle Aged Nephrectomy Polymorphism, Genetic Pyrimidines--adverse effects Sulfonamides--adverse effects