TY  - GEN
AU  - Sweeny,David J
AU  - Li,Weiqun
AU  - Clough,Jeffrey
AU  - Bhamidipati,Somasekhar
AU  - Singh,Rajinder
AU  - Park,Gary
AU  - Baluom,Muhammad
AU  - Grossbard,Elliott
AU  - Lau,David T-W
TI  - Metabolism of fostamatinib, the oral methylene phosphate prodrug of the spleen tyrosine kinase inhibitor R406 in humans: contribution of hepatic and gut bacterial processes to the overall biotransformation
SN  - 1521-009X
PY  - 2010///1012
KW  - Adult
KW  - Aminopyridines
KW  - Bacteria, Anaerobic
KW  - metabolism
KW  - Biotransformation
KW  - Gastrointestinal Tract
KW  - Humans
KW  - In Vitro Techniques
KW  - Inactivation, Metabolic
KW  - Liver
KW  - Male
KW  - Microsomes
KW  - Morpholines
KW  - Oxazines
KW  - pharmacokinetics
KW  - Prodrugs
KW  - Pyridines
KW  - Pyrimidines
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1124/dmd.110.032151
ER  -