Ramana, Kota V <br/><br/>
Inhibition of aldose reductase prevents growth factor-induced G1-S phase transition through the AKT/phosphoinositide 3-kinase/E2F-1 pathway in human colon cancer cells.  [electronic resource] 

 -  Molecular cancer therapeutics  Apr 2010 
 - 813-24 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural 
<br/><br/><label>ISSN: </label>1538-8514 
<br/><br/><label>Standard No.: </label>10.1158/1535-7163.MCT-09-0795  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aldehyde Reductase--antagonists & inhibitors<br/>Animals<br/>Benzothiazoles--pharmacology<br/>Cell Cycle--drug effects<br/>Cell Cycle Proteins--genetics<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Colonic Neoplasms--enzymology<br/>DNA, Neoplasm--metabolism<br/>E2F1 Transcription Factor--genetics<br/>G1 Phase--drug effects<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Humans<br/>Imidazolidines--pharmacology<br/>Intercellular Signaling Peptides and Proteins--pharmacology<br/>Mice<br/>Neoplasm Proteins--genetics<br/>Phosphatidylinositol 3-Kinases--metabolism<br/>Phosphorylation--drug effects<br/>Phthalazines--pharmacology<br/>Protein Binding--drug effects<br/>Proto-Oncogene Proteins c-akt--metabolism<br/>RNA, Messenger--genetics<br/>Retinoblastoma Protein--metabolism<br/>S Phase--drug effects<br/>Signal Transduction--drug effects<br/>Xenograft Model Antitumor Assays