Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Abeta1-40. [electronic resource]
- Journal of neuroinflammation Mar 2010
- 22 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1742-2094
10.1186/1742-2094-7-22 doi
Amyloid beta-Peptides--metabolism Amyloid beta-Protein Precursor--physiology Blotting, Western Brain Chemistry--physiology Cell Adhesion--physiology Cell Line Cerebrovascular Circulation--physiology Collagen Type I--metabolism Enzyme-Linked Immunosorbent Assay Humans Immunoprecipitation Inflammation--pathology Interleukin-1beta--metabolism Peptide Fragments--metabolism Protein Kinase Inhibitors--pharmacology Protein-Tyrosine Kinases--physiology RNA, Small Interfering Signal Transduction--physiology Transfection p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors src-Family Kinases--antagonists & inhibitors