IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun. [electronic resource]
- Journal of cellular biochemistry May 2010
- 248-59 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
1097-4644
10.1002/jcb.22532 doi
Cell Line Curcumin--pharmacology Extracellular Signal-Regulated MAP Kinases--metabolism Gene Expression Regulation, Enzymologic--drug effects Glucose--pharmacology Humans Interleukin-6--pharmacology JNK Mitogen-Activated Protein Kinases--metabolism Lipopolysaccharides--pharmacology MAP Kinase Signaling System--drug effects Matrix Metalloproteinase 1--genetics Mitogen-Activated Protein Kinase 1--metabolism Mitogen-Activated Protein Kinase 3--metabolism Monocytes--drug effects Phagocytes--drug effects Proto-Oncogene Proteins c-jun--metabolism Simvastatin--pharmacology Tissue Inhibitor of Metalloproteinases--genetics Up-Regulation--drug effects