DPD-based adaptive dosing of 5-FU in patients with head and neck cancer: impact on treatment efficacy and toxicity. [electronic resource]
- Cancer chemotherapy and pharmacology Jan 2011
- 49-56 p. digital
Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't
1432-0843
10.1007/s00280-010-1282-4 doi
Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic--administration & dosage Dihydropyrimidine Dehydrogenase Deficiency--genetics Dihydrouracil Dehydrogenase (NADP)--genetics Dose-Response Relationship, Drug Female Fluorouracil--administration & dosage Head and Neck Neoplasms--drug therapy Humans Male Middle Aged Pharmacogenetics Prospective Studies Retrospective Studies Severity of Illness Index Treatment Outcome