TY  - GEN
AU  - Williams,Olusegun
AU  - Houseman,Benjamin T
AU  - Kunkel,Eric J
AU  - Aizenstein,Brian
AU  - Hoffman,Randy
AU  - Knight,Zachary A
AU  - Shokat,Kevan M
TI  - Discovery of dual inhibitors of the immune cell PI3Ks p110delta and p110gamma: a prototype for new anti-inflammatory drugs
SN  - 1879-1301
PY  - 2010///0608
KW  - Anti-Inflammatory Agents
KW  - chemical synthesis
KW  - Cells, Cultured
KW  - Class I Phosphatidylinositol 3-Kinases
KW  - Class Ib Phosphatidylinositol 3-Kinase
KW  - Drug Discovery
KW  - Enzyme Inhibitors
KW  - Humans
KW  - Isoenzymes
KW  - antagonists & inhibitors
KW  - Lipopolysaccharides
KW  - toxicity
KW  - Lymphocyte Activation
KW  - Phosphatidylinositol 3-Kinases
KW  - metabolism
KW  - Phosphoinositide-3 Kinase Inhibitors
KW  - Quinazolinones
KW  - Signal Transduction
KW  - Tumor Necrosis Factor-alpha
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1016/j.chembiol.2010.01.010
ER  -