TY  - GEN
AU  - Tsou,Hwei-Ru
AU  - MacEwan,Gloria
AU  - Birnberg,Gary
AU  - Grosu,George
AU  - Bursavich,Matthew G
AU  - Bard,Joel
AU  - Brooijmans,Natasja
AU  - Toral-Barza,Lourdes
AU  - Hollander,Irwin
AU  - Mansour,Tarek S
AU  - Ayral-Kaloustian,Semiramis
AU  - Yu,Ker
TI  - Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR)
SN  - 1464-3405
PY  - 2010///0705
KW  - Adenosine Triphosphate
KW  - metabolism
KW  - Animals
KW  - Antineoplastic Agents
KW  - chemistry
KW  - Benzofurans
KW  - Crystallography, X-Ray
KW  - Humans
KW  - Inhibitory Concentration 50
KW  - Intracellular Signaling Peptides and Proteins
KW  - antagonists & inhibitors
KW  - Mice
KW  - Mice, Nude
KW  - Microsomes
KW  - Models, Molecular
KW  - Neoplasms
KW  - drug therapy
KW  - Phosphatidylinositol 3-Kinases
KW  - Protein Kinase Inhibitors
KW  - Protein Serine-Threonine Kinases
KW  - Structure-Activity Relationship
KW  - TOR Serine-Threonine Kinases
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2010.01.135
ER  -