Tsou, Hwei-Ru <br/><br/>
Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR).  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Apr 2010 
 - 2321-5 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2010.01.135  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Adenosine Triphosphate--metabolism<br/>Animals<br/>Antineoplastic Agents--chemistry<br/>Benzofurans--chemistry<br/>Crystallography, X-Ray<br/>Humans<br/>Inhibitory Concentration 50<br/>Intracellular Signaling Peptides and Proteins--antagonists & inhibitors<br/>Mice<br/>Mice, Nude<br/>Microsomes--metabolism<br/>Models, Molecular<br/>Neoplasms--drug therapy<br/>Phosphatidylinositol 3-Kinases--chemistry<br/>Protein Kinase Inhibitors--chemistry<br/>Protein Serine-Threonine Kinases--antagonists & inhibitors<br/>Structure-Activity Relationship<br/>TOR Serine-Threonine Kinases