TY  - GEN
AU  - Shen,Hong C
AU  - Ding,Fa-Xiang
AU  - Raghavan,Subharekha
AU  - Deng,Qiaolin
AU  - Luell,Silvi
AU  - Forrest,Michael J
AU  - Carballo-Jane,Ester
AU  - Wilsie,Larissa C
AU  - Krsmanovic,Mihajlo L
AU  - Taggart,Andrew K
AU  - Wu,Kenneth K
AU  - Wu,Tsuei-Ju
AU  - Cheng,Kang
AU  - Ren,Ning
AU  - Cai,Tian-Quan
AU  - Chen,Qing
AU  - Wang,Junying
AU  - Wolff,Michael S
AU  - Tong,Xinchun
AU  - Holt,Tom G
AU  - Waters,M Gerard
AU  - Hammond,Milton L
AU  - Tata,James R
AU  - Colletti,Steven L
TI  - Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate
SN  - 1520-4804
PY  - 2010///0504
KW  - Animals
KW  - Area Under Curve
KW  - Binding, Competitive
KW  - CHO Cells
KW  - Carboxylic Acids
KW  - chemistry
KW  - Cricetinae
KW  - Cricetulus
KW  - Cyclohexanecarboxylic Acids
KW  - Cyclohexenes
KW  - Dogs
KW  - Drug Discovery
KW  - Drug Evaluation, Preclinical
KW  - Fatty Acids, Nonesterified
KW  - blood
KW  - Humans
KW  - Metabolic Clearance Rate
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Mice, Knockout
KW  - Models, Chemical
KW  - Molecular Structure
KW  - Oxadiazoles
KW  - Rats
KW  - Receptors, G-Protein-Coupled
KW  - agonists
KW  - Receptors, Nicotinic
KW  - genetics
KW  - Structure-Activity Relationship
KW  - Vasodilation
KW  - drug effects
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1021/jm100022r
ER  -