Shen, Hong C <br/><br/>
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.  [electronic resource] 

 -  Journal of medicinal chemistry  Mar 2010 
 - 2666-70 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm100022r  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Area Under Curve<br/>Binding, Competitive<br/>CHO Cells<br/>Carboxylic Acids--chemistry<br/>Cricetinae<br/>Cricetulus<br/>Cyclohexanecarboxylic Acids--chemistry<br/>Cyclohexenes--chemistry<br/>Dogs<br/>Drug Discovery<br/>Drug Evaluation, Preclinical<br/>Fatty Acids, Nonesterified--blood<br/>Humans<br/>Metabolic Clearance Rate<br/>Mice<br/>Mice, Inbred C57BL<br/>Mice, Knockout<br/>Models, Chemical<br/>Molecular Structure<br/>Oxadiazoles--chemistry<br/>Rats<br/>Receptors, G-Protein-Coupled--agonists<br/>Receptors, Nicotinic--genetics<br/>Structure-Activity Relationship<br/>Vasodilation--drug effects