TY - GEN AU - López Castel,Arturo AU - Cleary,John D AU - Pearson,Christopher E TI - Repeat instability as the basis for human diseases and as a potential target for therapy SN - 1471-0080 PY - 2010///0423 KW - Animals KW - Base Sequence KW - DNA Damage KW - drug effects KW - DNA Repair KW - DNA Replication KW - Drug Therapy KW - methods KW - Genetic Predisposition to Disease KW - genetics KW - Genomic Instability KW - Humans KW - Mice KW - Models, Biological KW - Transcription, Genetic KW - Trinucleotide Repeat Expansion KW - Trinucleotide Repeats N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review UR - https://doi.org/10.1038/nrm2854 ER -