TY  - GEN
AU  - Rajapakse,Hemaka A
AU  - Nantermet,Philippe G
AU  - Selnick,Harold G
AU  - Barrow,James C
AU  - McGaughey,Georgia B
AU  - Munshi,Sanjeev
AU  - Lindsley,Stacey R
AU  - Young,Mary Beth
AU  - Ngo,Phung L
AU  - Holloway,M Katherine
AU  - Lai,Ming-Tain
AU  - Espeseth,Amy S
AU  - Shi,Xiao-Ping
AU  - Colussi,Dennis
AU  - Pietrak,Beth
AU  - Crouthamel,Ming-Chih
AU  - Tugusheva,Katherine
AU  - Huang,Qian
AU  - Xu,Min
AU  - Simon,Adam J
AU  - Kuo,Lawrence
AU  - Hazuda,Daria J
AU  - Graham,Samuel
AU  - Vacca,Joseph P
TI  - SAR of tertiary carbinamine derived BACE1 inhibitors: role of aspartate ligand amine pKa in enzyme inhibition
SN  - 1464-3405
PY  - 2010///0713
KW  - Amines
KW  - metabolism
KW  - Amyloid Precursor Protein Secretases
KW  - antagonists & inhibitors
KW  - Aspartic Acid
KW  - Aspartic Acid Endopeptidases
KW  - Catalysis
KW  - Enzyme Inhibitors
KW  - pharmacology
KW  - Humans
KW  - Models, Molecular
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2010.01.137
ER  -