TY  - GEN
AU  - Walsh,Ann W
AU  - Langley,David R
AU  - Colonno,Richard J
AU  - Tenney,Daniel J
TI  - Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir
SN  - 1932-6203
PY  - 2010///0930
KW  - Amino Acid Sequence
KW  - Amino Acid Substitution
KW  - Antiviral Agents
KW  - pharmacology
KW  - Binding Sites
KW  - genetics
KW  - Drug Resistance, Viral
KW  - Guanine
KW  - analogs & derivatives
KW  - Guanosine Triphosphate
KW  - chemistry
KW  - Hep G2 Cells
KW  - Hepatitis B virus
KW  - enzymology
KW  - Humans
KW  - Hydrogen Bonding
KW  - Kinetics
KW  - Lamivudine
KW  - Models, Molecular
KW  - Protein Binding
KW  - Protein Structure, Tertiary
KW  - RNA-Directed DNA Polymerase
KW  - Substrate Specificity
KW  - Viral Proteins
KW  - Virus Replication
KW  - drug effects
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1371/journal.pone.0009195
ER  -