TY  - GEN
AU  - Nourry,Arnaud
AU  - Zambon,Alfonso
AU  - Davies,Lawrence
AU  - Niculescu-Duvaz,Ion
AU  - Dijkstra,Harmen P
AU  - Ménard,Delphine
AU  - Gaulon,Catherine
AU  - Niculescu-Duvaz,Dan
AU  - Suijkerbuijk,Bart M J M
AU  - Friedlos,Frank
AU  - Manne,Helen A
AU  - Kirk,Ruth
AU  - Whittaker,Steven
AU  - Marais,Richard
AU  - Springer,Caroline J
TI  - BRAF inhibitors based on an imidazo[4,5]pyridin-2-one scaffold and a meta substituted middle ring
SN  - 1520-4804
PY  - 2010///0401
KW  - Antineoplastic Agents
KW  - chemical synthesis
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - drug effects
KW  - Humans
KW  - Imidazoles
KW  - Inhibitory Concentration 50
KW  - Magnetic Resonance Spectroscopy
KW  - Mass Spectrometry
KW  - Models, Molecular
KW  - Phosphorylation
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins B-raf
KW  - antagonists & inhibitors
KW  - Pyridones
KW  - Structure-Activity Relationship
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/jm901509a
ER  -