A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. [electronic resource]
- Clinical pharmacology and therapeutics Jun 2010
- 735-42 p. digital
Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1532-6535
10.1038/clpt.2009.253 doi
ATP Binding Cassette Transporter, Subfamily B, Member 1--drug effects Adult Anti-HIV Agents--pharmacology Area Under Curve Cytochrome P-450 Enzyme System--drug effects Drug Combinations Drug Interactions Enzyme Induction--drug effects Enzyme Inhibitors--pharmacology Female Genotype HIV Protease Inhibitors--pharmacology Humans Intestinal Mucosa--metabolism Liver--metabolism Male Pharmaceutical Preparations--administration & dosage Phenotype Polymorphism, Single Nucleotide Pyridines--pharmacology Pyrones--pharmacology Ritonavir--pharmacology Sulfonamides Young Adult