TY  - GEN
AU  - Contreras,Cristina M
AU  - Akbay,Esra A
AU  - Gallardo,Teresa D
AU  - Haynie,J Marshall
AU  - Sharma,Sreenath
AU  - Tagao,Osamu
AU  - Bardeesy,Nabeel
AU  - Takahashi,Masaya
AU  - Settleman,Jeff
AU  - Wong,Kwok-Kin
AU  - Castrillon,Diego H
TI  - Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy
SN  - 1754-8411
PY  - 2010///0526
KW  - AMP-Activated Protein Kinases
KW  - Animals
KW  - Cell Line, Tumor
KW  - Cloning, Molecular
KW  - Cornified Envelope Proline-Rich Proteins
KW  - genetics
KW  - Disease Models, Animal
KW  - Drug Screening Assays, Antitumor
KW  - Endometrial Neoplasms
KW  - drug therapy
KW  - Endometrium
KW  - drug effects
KW  - Enzyme Activation
KW  - Epithelium
KW  - Female
KW  - Integrases
KW  - metabolism
KW  - Intracellular Signaling Peptides and Proteins
KW  - antagonists & inhibitors
KW  - Mice
KW  - Mice, Transgenic
KW  - Neoplasm Invasiveness
KW  - Organ Specificity
KW  - Penetrance
KW  - Protein Kinase Inhibitors
KW  - pharmacology
KW  - Protein Serine-Threonine Kinases
KW  - Response Elements
KW  - Sirolimus
KW  - TOR Serine-Threonine Kinases
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1242/dmm.004440
ER  -