TY  - GEN
AU  - Vourvahis,Manoli
AU  - Gleave,Michelle
AU  - Nedderman,Angus N R
AU  - Hyland,Ruth
AU  - Gardner,Iain
AU  - Howard,Martin
AU  - Kempshall,Sarah
AU  - Collins,Claire
AU  - LaBadie,Robert
TI  - Excretion and metabolism of lersivirine (5-{[3,5-diethyl-1-(2-hydroxyethyl)(3,5-14C2)-1H-pyrazol-4-yl]oxy}benzene-1,3-dicarbonitrile), a next-generation non-nucleoside reverse transcriptase inhibitor, after administration of [14C]Lersivirine to healthy volunteers
SN  - 1521-009X
PY  - 2010///0917
KW  - Adult
KW  - Anti-HIV Agents
KW  - adverse effects
KW  - Area Under Curve
KW  - Biocatalysis
KW  - Cytochrome P-450 CYP3A
KW  - metabolism
KW  - Dealkylation
KW  - Feces
KW  - chemistry
KW  - Glucuronidase
KW  - Glucuronides
KW  - analysis
KW  - Glucuronosyltransferase
KW  - Humans
KW  - Hydrolysis
KW  - Hydroxylation
KW  - Kinetics
KW  - Male
KW  - Microsomes, Liver
KW  - enzymology
KW  - Middle Aged
KW  - Molecular Structure
KW  - Nitriles
KW  - Oxidation-Reduction
KW  - Pyrazoles
KW  - Recombinant Proteins
KW  - Reverse Transcriptase Inhibitors
KW  - Sulfates
KW  - Tandem Mass Spectrometry
N1  - Publication Type: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1124/dmd.109.031252
ER  -