Mahadeo, Kris M <br/><br/>
Subacute methotrexate neurotoxicity and cerebral venous sinus thrombosis in a 12-year-old with acute lymphoblastic leukemia and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: homocysteine-mediated methotrexate neurotoxicity via direct endothelial injury.  [electronic resource] 

 -  Pediatric hematology and oncology  Feb 2010 
 - 46-52 p.  digital 
<br/><br/> Publication Type: Case Reports; Journal Article 
<br/><br/><label>ISSN: </label>1521-0669 
<br/><br/><label>Standard No.: </label>10.3109/08880010903341904  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Substitution<br/>Antineoplastic Combined Chemotherapy Protocols--therapeutic use<br/>Asparaginase--therapeutic use<br/>Child<br/>Cytarabine--therapeutic use<br/>Daunorubicin--therapeutic use<br/>Endothelium, Vascular--drug effects<br/>Epilepsy, Tonic-Clonic--chemically induced<br/>Genetic Predisposition to Disease<br/>Humans<br/>Hyperhomocysteinemia--complications<br/>Injections, Spinal<br/>Leukoencephalopathies--chemically induced<br/>Male<br/>Methotrexate--administration & dosage<br/>Methylenetetrahydrofolate Reductase (NADPH2)--genetics<br/>Polymorphism, Single Nucleotide<br/>Precursor B-Cell Lymphoblastic Leukemia-Lymphoma--complications<br/>Prednisone--therapeutic use<br/>Remission Induction<br/>Sinus Thrombosis, Intracranial--chemically induced<br/>Vincristine--therapeutic use