Moreno-Rubio, Juan <br/><br/>
Nonsteroidal antiinflammatory drugs and prostaglandin E(2) modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis.  [electronic resource] 

 -  Arthritis and rheumatism  Feb 2010 
 - 478-88 p.  digital 
<br/><br/> Publication Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>0004-3591 
<br/><br/><label>Standard No.: </label>10.1002/art.27204  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Aged<br/>Aged, 80 and over<br/>Anti-Inflammatory Agents, Non-Steroidal--therapeutic use<br/>Celecoxib<br/>Cells, Cultured<br/>Chondrocytes--cytology<br/>Cyclooxygenase 2 Inhibitors--therapeutic use<br/>Dinoprostone--metabolism<br/>Dose-Response Relationship, Drug<br/>Gene Expression--drug effects<br/>Humans<br/>Immunohistochemistry<br/>Osteoarthritis, Knee--drug therapy<br/>Osteoprotegerin--genetics<br/>Pyrazoles--therapeutic use<br/>RANK Ligand--genetics<br/>Receptors, Prostaglandin E--agonists<br/>Severity of Illness Index<br/>Signal Transduction--drug effects<br/>Sulfonamides--therapeutic use