TY - GEN AU - Huang,Dan AU - Ding,Yan AU - Li,Yan AU - Luo,Wang-Mei AU - Zhang,Zhong-Fa AU - Snider,John AU - Vandenbeldt,Kristin AU - Qian,Chao-Nan AU - Teh,Bin Tean TI - Sunitinib acts primarily on tumor endothelium rather than tumor cells to inhibit the growth of renal cell carcinoma SN - 1538-7445 PY - 2010///0309 KW - Angiogenesis Inhibitors KW - pharmacology KW - Animals KW - Blotting, Western KW - Carcinoma, Renal Cell KW - blood supply KW - Cell Line KW - Cell Line, Tumor KW - Cell Movement KW - drug effects KW - Cell Proliferation KW - Dose-Response Relationship, Drug KW - Endothelial Cells KW - cytology KW - Endothelium, Vascular KW - Female KW - Humans KW - Indoles KW - Kidney Neoplasms KW - Mice KW - Mice, Inbred BALB C KW - Mice, Nude KW - Neovascularization, Pathologic KW - genetics KW - Pyrroles KW - RNA Interference KW - Receptor, Platelet-Derived Growth Factor beta KW - Sunitinib KW - Tumor Burden KW - Vascular Endothelial Growth Factor Receptor-2 KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/0008-5472.CAN-09-3722 ER -