TY - GEN AU - Matveev,Alexander V AU - Fitzgerald,J Browning AU - Xu,Jianhua AU - Malykhina,Anna P AU - Rodgers,Karla K AU - Ding,Xi-Qin TI - The disease-causing mutations in the carboxyl terminus of the cone cyclic nucleotide-gated channel CNGA3 subunit alter the local secondary structure and interfere with the channel active conformational change SN - 1520-4995 PY - 2010///0316 KW - Animals KW - Blotting, Western KW - Calcium KW - metabolism KW - Cell Line KW - Circular Dichroism KW - Cyclic Nucleotide-Gated Cation Channels KW - chemistry KW - Electrophoresis, Polyacrylamide Gel KW - Electrophysiology KW - Escherichia coli KW - genetics KW - Fluorescent Antibody Technique KW - Humans KW - Mice KW - Microscopy, Confocal KW - Models, Biological KW - Mutation KW - Protein Stability KW - Protein Structure, Secondary KW - Recombinant Proteins KW - Structure-Activity Relationship N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1021/bi901960u ER -