Inhibition of PTP1B by trodusquemine (MSI-1436) causes fat-specific weight loss in diet-induced obese mice. [electronic resource]
- Obesity (Silver Spring, Md.) Aug 2010
- 1516-23 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural
1930-739X
10.1038/oby.2009.444 doi
Animals Appetite--drug effects Body Composition--drug effects Cholestanes--pharmacology Diet Disease Models, Animal Hep G2 Cells Humans Hypolipidemic Agents--pharmacology Hypothalamus--drug effects Insulin--blood Leptin--blood Male Mice Mice, Inbred AKR Mice, Obese Obesity--drug therapy Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 1--antagonists & inhibitors Receptor, Insulin--metabolism STAT3 Transcription Factor--metabolism Spermine--analogs & derivatives Weight Loss--drug effects