TY  - GEN
AU  - Sabisz,Michal
AU  - Wesierska-Gadek,Józefa
AU  - Skladanowski,Andrzej
TI  - Increased cytotoxicity of an unusual DNA topoisomerase II inhibitor compound C-1305 toward HeLa cells with downregulated PARP-1 activity results from re-activation of the p53 pathway and modulation of mitotic checkpoints
SN  - 1873-2968
PY  - 2010///0408
KW  - Acridines
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Blotting, Western
KW  - Cell Cycle
KW  - Cell Death
KW  - Cyclin B1
KW  - physiology
KW  - DNA Damage
KW  - Dose-Response Relationship, Drug
KW  - Down-Regulation
KW  - Flow Cytometry
KW  - Gene Expression Regulation
KW  - HeLa Cells
KW  - Humans
KW  - Mitosis
KW  - Poly (ADP-Ribose) Polymerase-1
KW  - Poly(ADP-ribose) Polymerase Inhibitors
KW  - Poly(ADP-ribose) Polymerases
KW  - metabolism
KW  - Polyploidy
KW  - Proteasome Endopeptidase Complex
KW  - Quinazolines
KW  - Topoisomerase II Inhibitors
KW  - Triazoles
KW  - Tumor Suppressor Protein p53
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.bcp.2009.12.023
ER  -