TY - GEN AU - Pacholec,Michelle AU - Bleasdale,John E AU - Chrunyk,Boris AU - Cunningham,David AU - Flynn,Declan AU - Garofalo,Robert S AU - Griffith,David AU - Griffor,Matt AU - Loulakis,Pat AU - Pabst,Brandon AU - Qiu,Xiayang AU - Stockman,Brian AU - Thanabal,Venkataraman AU - Varghese,Alison AU - Ward,Jessica AU - Withka,Jane AU - Ahn,Kay TI - SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1 SN - 1083-351X PY - 2010///0415 KW - Acetylation KW - drug effects KW - Allosteric Regulation KW - Animals KW - Blood Glucose KW - Calorimetry KW - Diabetes Mellitus, Type 2 KW - drug therapy KW - Dietary Fats KW - pharmacology KW - Enzyme Activation KW - Enzyme Inhibitors KW - chemistry KW - Heterocyclic Compounds, 4 or More Rings KW - Humans KW - Mice KW - Mice, Obese KW - Nuclear Magnetic Resonance, Biomolecular KW - Resveratrol KW - Rhodamines KW - Sirtuin 1 KW - metabolism KW - Stilbenes KW - Substrate Specificity KW - Surface Plasmon Resonance KW - Tumor Suppressor Protein p53 N1 - Publication Type: Journal Article UR - https://doi.org/10.1074/jbc.M109.088682 ER -