A novel inhibitor of the PI3K/Akt pathway based on the structure of inositol 1,3,4,5,6-pentakisphosphate. [electronic resource]
- British journal of cancer Jan 2010
- 104-14 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1532-1827
10.1038/sj.bjc.6605408 doi
Adenocarcinoma--drug therapy Animals Antineoplastic Agents--chemical synthesis Apoptosis--drug effects Cell Line, Tumor--drug effects Drug Delivery Systems Drug Design Enzyme Activation--drug effects Female Humans Inositol Phosphates--chemical synthesis Intracellular Signaling Peptides and Proteins--drug effects Male Mice Mice, Nude Molecular Structure Ovarian Neoplasms--drug therapy Phosphoinositide-3 Kinase Inhibitors Prostatic Neoplasms--drug therapy Protein Kinase Inhibitors--chemical synthesis Protein Serine-Threonine Kinases--drug effects Proto-Oncogene Proteins c-akt--antagonists & inhibitors Signal Transduction--drug effects Structure-Activity Relationship TOR Serine-Threonine Kinases Xenograft Model Antitumor Assays