TY  - GEN
AU  - Hong,Bo
AU  - Lui,Vivian W Y
AU  - Hui,Edwin P
AU  - Ng,Margaret H L
AU  - Cheng,Suk-Hang
AU  - Sung,Fion L
AU  - Tsang,Chi-Man
AU  - Tsao,Sai-Wah
AU  - Chan,Anthony Tak-Cheung
TI  - Hypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation
SN  - 1573-0646
PY  - 2011///0906
KW  - Antineoplastic Agents
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Carcinoma
KW  - Cell Hypoxia
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Checkpoint Kinase 1
KW  - Checkpoint Kinase 2
KW  - Drug Screening Assays, Antitumor
KW  - Enzyme Activation
KW  - Gene Expression Regulation, Neoplastic
KW  - Genome, Viral
KW  - genetics
KW  - Herpesvirus 4, Human
KW  - Humans
KW  - Hypoxia-Inducible Factor 1, alpha Subunit
KW  - antagonists & inhibitors
KW  - Nasopharyngeal Carcinoma
KW  - Nasopharyngeal Neoplasms
KW  - enzymology
KW  - Poly(ADP-ribose) Polymerases
KW  - metabolism
KW  - Protein Kinases
KW  - Protein Serine-Threonine Kinases
KW  - S Phase
KW  - Signal Transduction
KW  - Tirapazamine
KW  - Triazines
KW  - Up-Regulation
KW  - Viral Matrix Proteins
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1007/s10637-009-9356-z
ER  -