Hong, Bo <br/><br/>
Hypoxia-targeting by tirapazamine (TPZ) induces preferential growth inhibition of nasopharyngeal carcinoma cells with Chk1/2 activation.  [electronic resource] 

 -  Investigational new drugs  Jun 2011 
 - 401-10 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1573-0646 
<br/><br/><label>Standard No.: </label>10.1007/s10637-009-9356-z  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Antineoplastic Agents--pharmacology<br/>Apoptosis--drug effects<br/>Carcinoma<br/>Cell Hypoxia--drug effects<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Checkpoint Kinase 1<br/>Checkpoint Kinase 2<br/>Drug Screening Assays, Antitumor<br/>Enzyme Activation--drug effects<br/>Gene Expression Regulation, Neoplastic--drug effects<br/>Genome, Viral--genetics<br/>Herpesvirus 4, Human--genetics<br/>Humans<br/>Hypoxia-Inducible Factor 1, alpha Subunit--antagonists & inhibitors<br/>Nasopharyngeal Carcinoma<br/>Nasopharyngeal Neoplasms--enzymology<br/>Poly(ADP-ribose) Polymerases--metabolism<br/>Protein Kinases--metabolism<br/>Protein Serine-Threonine Kinases--metabolism<br/>S Phase--drug effects<br/>Signal Transduction--drug effects<br/>Tirapazamine<br/>Triazines--pharmacology<br/>Up-Regulation--drug effects<br/>Viral Matrix Proteins--metabolism