Extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase, through nuclear factor-kappaB and activator protein-1, contribute to caerulein-induced expression of substance P and neurokinin-1 receptors in pancreatic acinar cells. [electronic resource]
- The Journal of pharmacology and experimental therapeutics Mar 2010
- 940-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1521-0103
10.1124/jpet.109.160416 doi
Acute Disease Animals Ceruletide--pharmacology JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors Male Mice Mitogen-Activated Protein Kinase 1--antagonists & inhibitors Mitogen-Activated Protein Kinase 3--antagonists & inhibitors NF-kappa B--physiology Pancreas--cytology Pancreatitis--metabolism Phosphorylation Protein Precursors--biosynthesis Receptor, Cholecystokinin A--physiology Receptors, Neurokinin-1--biosynthesis Signal Transduction Substance P--biosynthesis Tachykinins--biosynthesis Transcription Factor AP-1--physiology