Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors. [electronic resource]
- Bioorganic & medicinal chemistry Jan 2010
- 292-304 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1464-3391
10.1016/j.bmc.2009.10.055 doi
Animals Cyclization Humans Imidazoles--chemical synthesis Mice Models, Molecular Protein Binding Protein Kinase Inhibitors--chemistry Proto-Oncogene Proteins B-raf--antagonists & inhibitors