TY - GEN AU - Romero,Philip A AU - Arnold,Frances H TI - Exploring protein fitness landscapes by directed evolution SN - 1471-0080 PY - 2009///1216 KW - Animals KW - Directed Molecular Evolution KW - Humans KW - Mutation KW - genetics KW - Proteins KW - chemistry N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review UR - https://doi.org/10.1038/nrm2805 ER -